B-Lymphoblastoid cell lines (B-LCL)

B-Lymphoblastoid cell lines (B-LCL), which are derived from lymphoblastoid native B lymphocytes, are established by infection with EBV (Epstein-Barr virus) and, after some cell passages, represent transformed B cell lines which can be maintained in continuous in vitro culture. As a rule, they are derived from peripheral blood and closely resemble native activated B lymphocytes as can be confirmed by their pattern of surface-expressed CD antigens.

B-LCL are, as intact cells or as DNA derived thereof, an almost unlimited source for molecular genetical, immunological and functional studies. B-LCL established from patients’ cellular material are convenient tools in tumor research and in studies of other, e.g., autoimmune diseases. A comparatively new field for the application of B-LCL is research on so-called rare diseases, because here the limited source of native cellular/genetic material can be overcome by applying these cell lines.

Organism	Human
Tissue	Blood
Disease	Plasma Cell Leukemia

Organism	Human
Tissue	Peripheral blood
Disease	Carcinoma

Organism	Human
Tissue	Peripheral blood
Disease	Carcinoma

Organism	Human
Tissue	Peripheral blood
Disease	Carcinoma

Organism	Human
Tissue	Peripheral blood
Disease	Carcinoma