HLA-typed cells

The human HLA-system (human leukocyte antigen system), also named MHC (major histocompatibility complex), is a highly polymorphic gene system, encoding for a huge number of different cell surface antigens which play a central role in the immune defense. Generally, the HLA system is divided into two classes: HLA class I (HLA -A, -B-, -C) and class II (HLA-DR, -DP, -DQ). HLA glycoproteins contribute decisively to the defense against foreign antigens (infections) as well as to the control of the immunological identity of a given individual. Indeed, it is the genetic system which was already at the beginning of the 20th century postulated by Paul Ehrlich to be responsible for the differentiation between “self” and “non-self”, or in other words, between tolerance (towards own tissue/organs) and active immune defense (against foreign invaders). Today, we know that HLA-antigens direct the sophisticated interplay between B- and T-lymphocytes during the specific defense of the so called acquired immune system.

In view of the medical system, HLA-antigens control the histocompatibility during organ or stem cell transplantation.  The more similar HLA systems of donor and recipient are, the less likely is a rejection of the transplanted tissue/organ. The HLA-system also plays an important role for the anti-tumor defense of the body. The importance of the HLA system is nowadays recognized for ever more diseases, especially for autoimmune diseases.

CLS endeavors to provide medical and immunological research institutions with a wide range of different HLA-haplotypes (i.e., the specific HLA-complex of a given individual). This is done by collecting B-LCL’s as well as different human tumor cell lines typed for the HLA-system.

Please click on the following button to review our HLA data