Human Neuroblastoma cell line GIMEN (Synonyms: Gi-ME-N; Gimen; Gimen1)  Organism:Homo sapiens (human) Ethnicity:Caucasian Age:3.5 years Gender:Female Tissue:Neuroblastoma Morphology:Epithelial Cell type:Neuroblastoma Growth Properties:Monolayer, adherent Description:This cell line was established from a bone marrow specimen of a stage IV neuroblastoma after six months of chemotherapy. Proliferation of Gimen cells is inhibited by IFN; FGF-2 is antimitogenic for them. IFN gamma reverses and IL-1 beta enhances this antimitogenic effect of FGF-2 (Scheil, 1994).  

Human Neuroblastoma cell line GIMEN (Synonyms: Gi-ME-N; Gimen; Gimen1)  Organism:Homo sapiens (human) Ethnicity:Caucasian Age:3.5 years Gender:Female Tissue:Neuroblastoma Morphology:Epithelial Cell type:Neuroblastoma Growth Properties:Monolayer, adherent Description:This cell line was established from a bone marrow specimen of a stage IV neuroblastoma after six months of chemotherapy. Proliferation of Gimen cells is inhibited by IFN; FGF-2 is antimitogenic for them. IFN gamma reverses and IL-1 beta enhances this antimitogenic effect of FGF-2 (Scheil, 1994).  

Human Brain Neuroblastoma cell line  Organism:Homo sapiens (human) Ethnicity:Caucasian Age:13 months old Gender:Male Tissue:Brain Morphology:Fibroblast Cell type:Neuroblastoma; Neuroblast, Fibroblast Growth Properties:Monolayer, adherent Description:There are two cell types present. A small neuroblast- like cell is predominant, and the other one is a large hyaline fibroblast. This cell line can be propagated to >80 serial subcultures.  

Human Brain Neuroblastoma cell line  Organism:Homo sapiens (human) Ethnicity:Caucasian Age:13 months old Gender:Male Tissue:Brain Morphology:Fibroblast Cell type:Neuroblastoma; Neuroblast, Fibroblast Growth Properties:Monolayer, adherent Description:There are two cell types present. A small neuroblast- like cell is predominant, and the other one is a large hyaline fibroblast. This cell line can be propagated to >80 serial subcultures.  

Human Brain Neuroblastoma cell line Kelly  Organism:Homo sapiens (human) Ethnicity:Caucasian Tissue:Brain Morphology:Adherent Celltype:Neuroblastoma Growth Properties:Monolayer, adherent Description:The Kelly cell line has been established from a patient with neuroblastoma. They possess a genomic amplification of the N-myc gene.  

Human Brain Neuroblastoma cell line Kelly  Organism:Homo sapiens (human) Ethnicity:Caucasian Tissue:Brain Morphology:Adherent Celltype:Neuroblastoma Growth Properties:Monolayer, adherent Description:The Kelly cell line has been established from a patient with neuroblastoma. They possess a genomic amplification of the N-myc gene.  

Human Neuroblastoma cell line SH-SY5Y  Organism:Homo sapiens (human) Age:4 years old Gender:Female Tissue:Brain (from metastatic site: bone marrow) Morphology:The cells grow as clusters of neuroblastic cells with multiple, short, fine cell processes (neurites). Cells will aggregate, form clumps and float; a confluent monolayer is not formed. Cell type:Neuroblast (neuroblastoma) Growth Properties:Loosely adherent; form clumps at high cell density Description:SH-SY5Y is one of three serially isolated neuroblast clones (SH-SY, SH-SY5, SH-SY5Y) of the human neuroblastoma cell line SK-N-SH which was established in 1970 from a metastatic bone tumor. The cells exhibit moderate levels of dopamine beta hydroxylase activity. They can convert glutamate to the neurotransmitter GABA. SH-SY5Y cells have a reported saturation density greater than 1 x 106 cells/cm2. The loss of neuronal characteristics has been described with increasing passage numbers (approx. passage 20). Neuronal markers or uptake of noradrenalin should be determined routinely. It is recommended not to use at passage numbers higher than 20 unless neuronal characteristics are controlled. Virus:The presence of SMRV in SH-SY5Y was detected at CLS by qPCR. Biosafety level:Although there is no incidince of infections of hosts other than Squirrel Monkey, it is recommended to handle SH-SY5Y cells as a potentially biohazardous material under Biosafety Level 2 containment.  

Human Neuroblastoma cell line SH-SY5Y  Organism:Homo sapiens (human) Age:4 years old Gender:Female Tissue:Brain (from metastatic site: bone marrow) Morphology:The cells grow as clusters of neuroblastic cells with multiple, short, fine cell processes (neurites). Cells will aggregate, form clumps and float; a confluent monolayer is not formed. Cell type:Neuroblast (neuroblastoma) Growth Properties:Loosely adherent; form clumps at high cell density Description:SH-SY5Y is one of three serially isolated neuroblast clones (SH-SY, SH-SY5, SH-SY5Y) of the human neuroblastoma cell line SK-N-SH which was established in 1970 from a metastatic bone tumor. The cells exhibit moderate levels of dopamine beta hydroxylase activity. They can convert glutamate to the neurotransmitter GABA. SH-SY5Y cells have a reported saturation density greater than 1 x 106 cells/cm2. The loss of neuronal characteristics has been described with increasing passage numbers (approx. passage 20). Neuronal markers or uptake of noradrenalin should be determined routinely. It is recommended not to use at passage numbers higher than 20 unless neuronal characteristics are controlled. Virus:The presence of SMRV in SH-SY5Y was detected at CLS by qPCR. Biosafety level:Although there is no incidince of infections of hosts other than Squirrel Monkey, it is recommended to handle SH-SY5Y cells as a potentially biohazardous material under Biosafety Level 2 containment.  

Human Neuroblastoma cell line SK-N-LO  Organism:Homo sapiens (human) Ethnicity:Caucasian Tissue:Neuroectodermal tissue Morphology:Epithelial Cell type:Neuroblastoma Growth Properties:Adherent, on collagen-coated flasks   DisclaimerThis cell line is licensed to CLS by a partnering university or research institute. The cell line may be subject to individual terms and licensing fees as required by the licensor. Please contact us for further information.

Human Neuroblastoma cell line SK-N-LO  Organism:Homo sapiens (human) Ethnicity:Caucasian Tissue:Neuroectodermal tissue Morphology:epithelial Cell type:Neuroblastoma Growth Properties:Adherent, on collagen-coated flasks   DisclaimerThis cell line is licensed to CLS by a partnering university or research institute. The cell line may be subject to individual terms and licensing fees as required by the licensor. Please contact us for further information.